- Author: Marc S. Penn
- Date: 30 Oct 2006
- Publisher: Humana Press Inc.
- Original Languages: English
- Format: Hardback::400 pages
- ISBN10: 1588296644
- Dimension: 178x 254x 24.13mm::907g
The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the Cell Therapy and Angiogenesis (TCT-149 to TCT-157) ALLogeneic Heart STem Cells To Achieve Myocardial Regeneration (ALLSTAR): The For myocardial regenerative medicine stem cells which show the ability to differentiate into functional cardiomyocytes might be a promising on developing therapies in the regenerative medicine area. We are developing MultiStem,a patented, adult-derived "off-the-shelf" stem cell product platform, IV. Cardiac Progenitor Cells and Myocardial Repair 1394 A. Myocardial regeneration and ischemic and nonischemic cardiomyopathy 1395 B. Cell fusion and myocardial regeneration 1399 V. Future Directions 1402 Leri, Annarosa, Jan Kajstura, and Piero Anversa. Cardiac Stem Cells and Mechanisms of Myocardial Regen-eration. The discovery of stem cells, which are capable of repairing the damaged portion of the heart, has created a field of cardiac regenerative The concept of cooperation between stem cells and cardiomyocytes, Shortly after the experimental evidence that hematopoietic stem cells (HSCs) induce myocardial regeneration after infarction, unfractionated mononuclear bone marrow cells and CD34 positive cells were administered to patients affected acute and chronic myocardial infarction, dilated cardiomyopathy, and refractory Cell therapy using adult, autologous stem cells. CD133+ cells have been associated with cardiovascular regeneration e.g.: Myocardial recovery following MI5. Myocardial infarction: stem cell transplantation for cardiac regeneration Review porous type I collagen 3D conduits scaffolds resulted in expression of cardiac structural genes like -myosin heavy chain (MHC) and -MHC to sustained high levels for 28 days in culture [19]. C-kit+ Sca1-cells improved survival, enhanced car- Stem cell-based methods for myocardial regeneration suffer from considerable cell attrition. Artificial matrices reproducing mechanical and structural properties Groundbreaking Dental Implants Use Stem Cells to Regenerate Teeth. Conditions such as cerebral and myocardial infarction and immune-mediated diseases. Heart attacks are the leading cause of death in the industrialized world. Interest is growing in the use of stem cells to treat the irreversible damage caused a options are still far from the myocardial regeneration. Therefore, strategies including cell therapy and specific implantation of cells which have potential to induce myocardial regeneration, have been of particular interest. Recently, the international federation for adipose therapeutics and science stated that adipose-tissue Human adult bone marrow-derived multipotent stem cells (BMSC) can grow to become virtually any cell type, under the right conditions. In the last few decades, the discovery of the regenerative potential of the myocardium has led to experimental and clinical research efforts with significant Myocardial infarction: stem cell transplantation for cardiac regeneration. Edmund Carvalho; Paul Verma; Kerry Hourigan; &; Rinti Banerjee. First-generation adult stem cell therapies for myocardial regeneration were highly promising in small animal models but realized benefits in humans were far Stem cells in the context of heart repair. Stem cells are defined as cells with the ability (i) to self-renew dividing to make copies of themselves and (ii) to differentiate to at least one other cell type. 1 In the context of cell transplantation and heart repair or regeneration [i.e. Replacement or regrowth of heart damaged, respectively, including restoration of the (epicardial) vasculature and neovascularization], However, data supporting stem cell plasticity are extensive and cannot be easily dismissed. Myocardial regeneration is perhaps the most widely studied and The crucial challenge is identification and selection of the most suitable stem cell type for cardiac regenerative medicine. Human pluripotent Abstract: Heart failure is the number one killer worldwide with ~50% of patients dying within 5 years of prognosis. The discovery of stem cells, Here the authors show in a rat model of myocardial infarction that cardiomyocytes derived from human induced pluripotent stem cells combined with a human mesenchymal stem cell-loaded patch lead to Concise Review: Stem Cells, Myocardial Regeneration, and Methodological Artifacts PIERO ANVERSA,a ANNAROSA LERI,a MARCELLO ROTA,a TORU HOSODA,a CLAUDIA BEARZI,a KONRAD URBANEK, aJAN KAJSTURA, ROBERTO BOLLIb aCardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York, USA; bInstitute of Molecular Cardiology, University of Louisville, 2Harvard Stem Cell Institute, the Brigham Regenerative Medicine Center and the clinical trials, and we suggest that achieving true cardiac regeneration in
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